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Androgenetic alopecia or baldness on man’s type — the most frequent form of loss of hair at men and makes to 95 % of all cases of baldness. Every third man suffers from it.
In what is the main reason of androgenetic alopecia?
Hypocrite and Aristotle gave the indirect answer to this question: they have noticed that eunuchs do not grow bald. Their supervision has proved to be true in the XX century, in researches of professor Hamilton. The main reason of androgenetic alopecia is constant damaging influence of molecules of man’s sexual hormones on a hair follicle. To understand the mechanism of this influence, it is necessary to familiarize with some theoretical bases.
There are three phases of life cycle of a follicle:
· In a phase of anagene hair is actively produced. The given phase lasts some years; in it there are 80-85 % of follicles.
· In a phase of katagene hair production stops. Lasts katagene about 3 months.
· In a phase of telogene hair slowly separates from a follicle and moves ahead to a skin surface. In this phase there are approximately 15 % of hair, and they are lost at washing of a head and combing. (Norm loss is to 100 hairs a day).
Influence of man’s sexual hormones.
Molecules of man’s sexual hormones (in particular, dehydro-testosterone) reduce duration of a growth phase — anagene, and prolong a rest phase — telogene. At androgenetic alopecia follicles will gradually atrophy, start to make weak hair. Eventually, this process comes to the end with a progressing and irreversible hair fall.
Why at alopecia all hair does not drop out?
The answer to this question consists in anatomic features of hair follicle. The follicles located in the field of a beard and moustaches, on a breast and feet and, the most important thing, in the field of a nape, have no especial receptors, the damaging action of molecules predisposed to perception of dehydro-testosterone. Thanks to level of hormonal activity does not influence their viability and functional activity.
Really, the majority of men have about identical level of sexual hormones and their derivative, and also active enzymes. The key factor in development of androgenetic alopecia is the heredity. If the genetic information on loss of hair is not present, negative influence of man’s sexual hormones comes to naught and baldness does not come.
It is found out that the gene of loss of hair in 73-75 % of cases is inherited on a parent line, in 20 % — on fatherly, and only 5-7 % of men are the first in a sort.
Thus, androgenetic alopecia — a consequence of symbiotic influence on hair follicles of two factors: hormonal activity and hereditary predisposition. This influence is actual only for hormonal dependent follicles (having special receptor) and has no value for anatomically protected follicles that are settling down in occipital area of a head.

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